This scene is so telling because it’s the only chance we get to see the effect that the separation from John has had on Sherlock. Sherlock is broken without John and Lestrade and Molly can see it. From here, we can inference that in all those hotel rooms where he worked to dismantle Moriarty’s web, Sherlock heard John’s voice even though he wasn’t there.
Sherlock is married to his work and his work, which he has worked on for most of his life, that he would kill and die for, has become John.
#married