So many of Whovians can relate to Donna, I don’t know how people hate her. This scene was tear city for me.
No but really. Look into her face for just a moment. Look at how in the first part she just passes the remark with a dejected look down. That look down is to save herself. She really isn’t important according to her and she thinks the Doctor knows this as well. And now look at his face. The light to it the friendly openness it almost always posses. Then look at it after he realizes She really believes that. He is so hurt and confused that someone he values so greatly could care little to nothing about themselves. He is beaten. Completely beaten that such an amazing person who means so much to him could mean nothing to herself. This kills me. I am so sorry.